66000-40-6

66000-40-6 structure

Name: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
Chemical Name: 2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine
CAS Number: 66000-40-6
Molecular Formula: C₁₀H₁₀F₃N₃
Molecular Weight: 229.20
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2017-08-16 17:58:56
Modify Date: 2024-01-02 11:54:56
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].

Name	2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine
Synonyms	BW-755C 1-(m-trifluoromethylphenyl)-3-amino-2-pyrazoline 1-[3-(trifluoromethyl)phenyl]-3-amino-2-pyrazoline 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine 1-(3-trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine 1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine 4,5-dihydro-1-(3-(trifluoromethyl)-phenyl)-1H-pyrazol-3-amine T0504-7356 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]- 1H-Pyrazol-3-amine, 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)- 3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline

Description	BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-LO:5 μM (IC50) COX-1:0.65 μg/mL (IC50) COX-2:1.2 μg/mL (IC50)
In Vivo	BW 755C (0.03-10 mg/rat; s.c.; once) 抑制大鼠排卵率及卵巢 5-HETE 和 12-HETE 水平[3]。 Animal Model: Immature Wistar rats ~22 days of age[3] Dosage: 0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat Administration: Subcutaneous injection, once Result: Reduced 5-HETE (moderately) and 12-HETE (strongly).
References	[1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70. [2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [3]. Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4.

HS Code	2933199090

107-13-1

368-78-5

66000-40-6

Literature: AKZO NOBEL N.V. Patent: US2007/112034 A1, 2007 ; Location in patent: Page/Page column 6 ;

3107-33-3

107-13-1

66000-40-6

Literature: American Cyanamid Company Patent: US4447442 A1, 1984 ;

126583-34-4

66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

126583-33-3

66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

126646-34-2

~75%

66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%