4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Modify Date: 2024-01-02 11:54:56

4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine structure	Common Name	4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
	CAS Number	66000-40-6	Molecular Weight	229.20
	Density	1.4±0.1 g/cm3	Boiling Point	308.5±52.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₀F₃N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	140.4±30.7 °C

Use of 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].

Name	2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine
Synonym	More Synonyms

Description	BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-LO:5 μM (IC50) COX-1:0.65 μg/mL (IC50) COX-2:1.2 μg/mL (IC50)
In Vivo	BW 755C (0.03-10 mg/rat; s.c.; once) 抑制大鼠排卵率及卵巢 5-HETE 和 12-HETE 水平[3]。 Animal Model: Immature Wistar rats ~22 days of age[3] Dosage: 0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat Administration: Subcutaneous injection, once Result: Reduced 5-HETE (moderately) and 12-HETE (strongly).
References	[1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70. [2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [3]. Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4.

Density	1.4±0.1 g/cm3
Boiling Point	308.5±52.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₀F₃N₃
Molecular Weight	229.20
Flash Point	140.4±30.7 °C
Exact Mass	229.082687
PSA	39.12000
LogP	1.94
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.559

HS Code	2933199090

Acrylonitrile

CAS#:107-13-1

3-(TRIFLUOROMET...

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4,5-dihydro-1-[...

CAS#:66000-40-6

Literature: AKZO NOBEL N.V. Patent: US2007/112034 A1, 2007 ; Location in patent: Page/Page column 6 ;

(3-(Trifluorome...

CAS#:3107-33-3

Acrylonitrile

CAS#:107-13-1

4,5-dihydro-1-[...

CAS#:66000-40-6

Literature: American Cyanamid Company Patent: US4447442 A1, 1984 ;

N/A

CAS#:126583-34-4

4,5-dihydro-1-[...

CAS#:66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

β-(3-trifluorom...

CAS#:126583-33-3

4,5-dihydro-1-[...

CAS#:66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

4,5-dihydro-3-(...

CAS#:126646-34-2

~75%

4,5-dihydro-1-[...

CAS#:66000-40-6

Literature: Frigola; Colombo; Pares; Martinez; Sagarra; Roser European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 435 - 445

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

BW-755C

1-(m-trifluoromethylphenyl)-3-amino-2-pyrazoline

1-[3-(trifluoromethyl)phenyl]-3-amino-2-pyrazoline

3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline

4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine

1-(3-trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine

1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine

4,5-dihydro-1-(3-(trifluoromethyl)-phenyl)-1H-pyrazol-3-amine

T0504-7356

1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-

1H-Pyrazol-3-amine, 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-

3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1600/5 mg

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4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Use of 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

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