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6686-02-8

6686-02-8 structure
6686-02-8 structure
  • Name: H-Trp-Phe-OH
  • Chemical Name: Trp-Phe
  • CAS Number: 6686-02-8
  • Molecular Formula: C20H21N3O3
  • Molecular Weight: 351.39900
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
  • Create Date: 2018-08-01 16:57:24
  • Modify Date: 2024-01-07 16:21:17
  • H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].
Name Trp-Phe
Synonyms 2-[[2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoic acid
L-tryptophyl-L-Phenylalanine
tryptophyl-L-phenylalanine
Description H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].
Related Catalog
References

[1]. Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs). Food Res Int. 2019 Jul;121:197-204.  

[2]. Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5(8), 378.

Density 1.319g/cm3
Boiling Point 688.3ºC at 760 mmHg
Molecular Formula C20H21N3O3
Molecular Weight 351.39900
Flash Point 370.1ºC
Exact Mass 351.15800
PSA 108.21000
LogP 2.94100
Index of Refraction 1.671

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY7582000
CHEMICAL NAME :
Alanine, 3-phenyl-N-tryptophyl-, L-
CAS REGISTRY NUMBER :
6686-02-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N3-O3
MOLECULAR WEIGHT :
351.44
WISWESSER LINE NOTATION :
T56 BMJ D1YZVMYVQ1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV. Volume(issue)/page/year: 20(Suppl 1),133A,1979
HS Code 2933990090
Precursor  0

DownStream  1

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 6686-02-8 | Chemsrc address: https://www.chemsrc.com/en/baike/606547.html

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