848142-62-1

848142-62-1 structure

Name: Indazole-Cl
Chemical Name: 3-chloro-2-(4-hydroxyphenyl)indazol-5-ol
CAS Number: 848142-62-1
Molecular Formula: C₁₃H₉ClN₂O₂
Molecular Weight: 260.68
Create Date: 2017-01-06 12:01:07
Modify Date: 2024-01-31 17:14:29
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inﬂammation in vascular smooth muscle cells (VSMCs)[1].

Name	3-chloro-2-(4-hydroxyphenyl)indazol-5-ol

Description	Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inﬂammation in vascular smooth muscle cells (VSMCs)[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
In Vitro	Indazole-Cl (0.1 μM；6 小时) 降低血管平滑肌细胞 (VSMC) 缺氧诱导的细胞内 ROS 水平[1]。 Indazole-Cl (10 μM；24 小时) 抑制 VSMC 中缺氧诱导的环氧合酶 (COX)-2 转录活性[1]。 Indazole-Cl (1 μM；24-72 小时) 可防止缺氧诱导的 VSMC 细胞迁移和侵袭[1]。
References	[1]. Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport