Indazole-Cl
Modify Date: 2024-01-31 17:14:29
Indazole-Cl structure
|
Common Name | Indazole-Cl | ||
|---|---|---|---|---|
| CAS Number | 848142-62-1 | Molecular Weight | 260.68 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H9ClN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Indazole-ClIndazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1]. |
| Name | 3-chloro-2-(4-hydroxyphenyl)indazol-5-ol |
|---|
| Description | Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
COX-2 |
| In Vitro | Indazole-Cl (0.1 μM；6 小时) 降低血管平滑肌细胞 (VSMC) 缺氧诱导的细胞内 ROS 水平[1]。 Indazole-Cl (10 μM；24 小时) 抑制 VSMC 中缺氧诱导的环氧合酶 (COX)-2 转录活性[1]。 Indazole-Cl (1 μM；24-72 小时) 可防止缺氧诱导的 VSMC 细胞迁移和侵袭[1]。 |
| References |
| Molecular Formula | C13H9ClN2O2 |
|---|---|
| Molecular Weight | 260.68 |
| Exact Mass | 260.03500 |
| PSA | 58.28000 |
| LogP | 3.09010 |
|
In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.
J. Biol. Chem. 291 , 58-71, (2016) Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutritional, or environmental sources into more eas... |
|
|
An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK.
Cell 4 , 584-95, (2011)
|
|
|
Estrogen receptor transrepresses brain inflammation. Gosselin D, Rivest S.
Cell 4 , 495-7, (2011)
|
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Indazole-Cl
- Price: Negotiable
- Purity: 98.72%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: Indazole-cl
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g ￥220.0/10ml
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link: