639-36-1

639-36-1 structure

Name: Akuammidine
Chemical Name: Akuammidine
CAS Number: 639-36-1
Molecular Formula: C₂₁H₂₄N₂O₃
Molecular Weight: 352.427
Catalog: Natural product Alkaloid
Create Date: 2017-08-16 00:38:01
Modify Date: 2024-01-02 23:55:04
Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].

Name	Akuammidine
Synonyms	Methyl (15α,19E)-17-hydroxysarpagan-16-carboxylate Sarpagan-16-carboxylic acid, 17-hydroxy-, methyl ester, (15α)-

Description	Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	Akuammidine treatment decreases the expression of IL-6 in cells[1][2].
References	[1]. Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104. [2]. J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8.

Hazard Codes	Xi