1186372-20-2
1186372-20-2 structure
- Name: TMN 355
- Chemical Name: 1-(2-chloro-6-fluorobenzoyl)-3-(9H-fluoren-9-yl)-urea
- CAS Number: 1186372-20-2
- Molecular Formula: C21H14ClFN2O2
- Molecular Weight: 380.79900
- Catalog: Signaling Pathways Others Others
- Create Date: 2019-08-10 21:18:50
- Modify Date: 2024-03-11 11:29:23
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TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].
| Name | 1-(2-chloro-6-fluorobenzoyl)-3-(9H-fluoren-9-yl)-urea |
|---|---|
| Synonyms | 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide |
| Description | TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1]. |
|---|---|
| Related Catalog | |
| Target |
cyclophilin A[1] |
| In Vitro | TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: THP cell lines Concentration: 0.5, 1, 2.5, 5 and 10 μM Incubation Time: 3, 6 and 9 hours Result: Resulted in 75.9% reduction of cyclophilin A protein expression. |
| References |
| Molecular Formula | C21H14ClFN2O2 |
|---|---|
| Molecular Weight | 380.79900 |
| Exact Mass | 380.07300 |
| PSA | 58.20000 |
| LogP | 5.47030 |
| Hazard Codes | Xi |
|---|