630-02-4

630-02-4 structure

Name: n-Octacosane
Chemical Name: octacosane
CAS Number: 630-02-4
Molecular Formula: C₂₈H₅₈
Molecular Weight: 394.76000
Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Acyclic hydrocarbon
Create Date: 2018-03-30 08:00:00
Modify Date: 2024-01-02 08:29:52
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].

Name	octacosane
Synonyms	N-o-Carbomethoxyphenyl-N'-phenylthiourea Benzoic acid,2-[[(phenylamino)thioxomethyl]amino]-,methyl ester EINECS 211-125-7 MFCD00009355 n-Octakosan n-Octacosane

Description	Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	Human Endogenous Metabolite
In Vitro	二十八烷 (12.5-100 μg/ml; 18 小时) 对 B16F10-Nex2 细胞具有很强的细胞毒活性，IC50 值为 41.08 μg/ml[1]。 Cell Cytotoxicity Assay[1] Cell Line: B16F10-Nex2 cells Concentration: 12.5, 25, 50, 100 μg/ml Incubation Time: 18 h Result: Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml
In Vivo	二十八烷 (500 μg; 在与原始细胞移植相关的外周部位注射; 每天; 35 天) 可显着延缓肿瘤进展，并具有显着的抗肿瘤作用[1]。 Animal Model: C57Bl/6 mice with B16F10-Nex2 Cellsl[1] Dosage: 500 μg Administration: Injected at peripheral sites in relation to the original cell grafting; daily; 35 days Result: Resulted in a significant delay of tumor progression with a significant antitumor effect. The survival rate of treated groups was significantly increased.
References	[1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. [2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.

Boiling Point	278 °C15 mm Hg(lit.)
Melting Point	57-62 °C(lit.)
Molecular Formula	C₂₈H₅₈
Molecular Weight	394.76000
Flash Point	227 °C
Exact Mass	394.45400
LogP	11.16880
Vapour density	13.6 (vs air)
Vapour Pressure	<1 mm Hg ( 20 °C)
Index of Refraction	1.4330 (70ºC)
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
Packaging Group	II; III
Hazard Class	4.1
HS Code	29011090

Precursor 10
30089-00-0 36247-34-4 19218-94-1 3893-01-4
50-00-0 88303-25-7 688-74-4 1700-37-4
3041-23-4 54509-73-8
DownStream 8
112-92-5 629-96-9 593-50-0 661-19-8
506-51-4 506-52-5 557-61-9 16416-33-4

HS Code	29011090

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