16416-33-4

16416-33-4 structure

Name: Octacosane-d58
Chemical Name: 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,28-octapentacontadeuteriooctacosane
CAS Number: 16416-33-4
Molecular Formula: C₂₈D₅₈
Molecular Weight: 453.117
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-07-17 18:32:08
Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].

Name	1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,28-octapentacontadeuteriooctacosane
Synonyms	Octacosane-d Octacosane-d58 MFCD00190493 (H)Octacosane

Description	Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. [3]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [4]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.

Density	0.8±0.1 g/cm3
Boiling Point	431.7±8.0 °C at 760 mmHg
Melting Point	61-63ºC(lit.)
Molecular Formula	C₂₈D₅₈
Molecular Weight	453.117
Flash Point	280.1±8.0 °C
Exact Mass	452.817902
LogP	15.63
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.450

RIDADR	NONH for all modes of transport

630-02-4

16416-33-4

Literature: Maegawa, Tomohiro; Fujiwara, Yuta; Inagaki, Yuya; Esaki, Hiroyoshi; Monguchi, Yasunari; Sajiki, Hironao Angewandte Chemie - International Edition, 2008 , vol. 47, # 29 p. 5394 - 5397

Precursor 1
630-02-4
DownStream 0

16416-33-4	872803-48-0
70926-47-5	630-02-4
16331-26-3	85774-68-1
89900-61-8	16331-21-8
68547-11-5	77388-62-6