Octacosane-d58

Modify Date: 2024-07-17 18:32:08

Octacosane-d58 structure	Common Name	Octacosane-d58
	CAS Number	16416-33-4	Molecular Weight	453.117
	Density	0.8±0.1 g/cm3	Boiling Point	431.7±8.0 °C at 760 mmHg
	Molecular Formula	C₂₈D₅₈	Melting Point	61-63ºC(lit.)
	MSDS	USA	Flash Point	280.1±8.0 °C

Use of Octacosane-d58

Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].

Name	1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,28-octapentacontadeuteriooctacosane
Synonym	More Synonyms

Description	Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. [3]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [4]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.

Density	0.8±0.1 g/cm3
Boiling Point	431.7±8.0 °C at 760 mmHg
Melting Point	61-63ºC(lit.)
Molecular Formula	C₂₈D₅₈
Molecular Weight	453.117
Flash Point	280.1±8.0 °C
Exact Mass	452.817902
LogP	15.63
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.450

RIDADR	NONH for all modes of transport

n-Octacosane

CAS#:630-02-4

Octacosane-d58

CAS#:16416-33-4

Literature: Maegawa, Tomohiro; Fujiwara, Yuta; Inagaki, Yuya; Esaki, Hiroyoshi; Monguchi, Yasunari; Sajiki, Hironao Angewandte Chemie - International Edition, 2008 , vol. 47, # 29 p. 5394 - 5397

Precursor 1
CAS#:630-02-4 n-Octacosane
DownStream 0

Octacosane-d

Octacosane-d58

MFCD00190493

(H)Octacosane

Octacosane-d58

Use of Octacosane-d58

Names

Octacosane-d58 Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms