166518-60-1

166518-60-1 structure

Name: Avasimibe
Chemical Name: [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid
CAS Number: 166518-60-1
Molecular Formula: C₂₉H₄₃NO₄S
Molecular Weight: 501.721
Catalog: Biochemical Inhibitor Metabolism P450 (eg CYP17) inhibitor
Create Date: 2018-03-27 08:00:00
Modify Date: 2024-01-01 21:58:48
Avasimibe is an oral inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively.

Name	[[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid
Synonyms	2,6-Diisopropylphenyl [(2,4,6-triisopropylphenyl)acetyl]sulfamate Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester [2,6-di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate 2,6-di(propan-2-yl)phenyl {[2,4,6-tri(propan-2-yl)phenyl]acetyl}sulfamate Avasimibe CI-1011

Description	Avasimibe is an oral inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Research Areas >> Cancer
References	[1]. Tardif JC et al. Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions. Circulation, 2004 Nov 23, 110(21):3372-7. [2]. Raal FJ et al. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia. Atherosclerosis, 2003 Dec, 171(2):273-9. [3]. Delsing DJ et al. Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Circulation, 2001 Apr 3, 103(13):1778-86.

CHEMICAL NAME :: Benzeneacetamide, N-((2,6-bis(1-methylethyl)phenoxy)sulfonyl)-2,4,6-tri s(1-methylethyl)-

TOXIC EFFECTS :: Behavioral - food intake (animal) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),274,1997

RIDADR	NONH for all modes of transport
HS Code	2935009090

52629-47-7

92050-02-7

~77%

166518-60-1

Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

57199-00-5

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Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

4276-88-4

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Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

4276-85-1

166518-60-1

Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

4276-84-0

166518-60-1

Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

166519-14-8

166518-60-1

Literature: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%