121083-05-4

121083-05-4 structure

Name: L-670,596
Chemical Name: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid
CAS Number: 121083-05-4
Molecular Formula: C₂₂H₂₁F₂NO₄S
Molecular Weight: 433.47
Create Date: 2018-12-12 18:34:41
Modify Date: 2024-04-02 17:42:20
L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069[1][2].

Name	2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid
Synonyms	R 568 hydrochloride HMS3268M18 L-670,596

Description	L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vitro	L-670596 抑制 U-44069 诱导的人类富血小板血浆的聚集[1]。
In Vivo	L-670596 (0.03 mg/kg ; i.v.; single) 抑制豚鼠中花生四烯酸和 U-44069 诱导的支气管收缩[1]。 L-670596 (2 mg/kg; i.v.; single) 抑制猪的血小板聚集成胶原蛋白[2]。 Animal Model: Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1]. Dosage: 0.03mg/kg Administration: Intravenous injection; single. Result: Inhibited arachidonic acid and U-44069 induced bronchoconstriction.
References	[1]. Ford-Hutchinson AW, et al. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93. [2]. Nuttall GA, et al. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan;74(1):138-45.