178600-17-4

178600-17-4 structure

Name: ZD 2079
Chemical Name: 2-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethoxy]phenyl]acetic acid,hydrochloride
CAS Number: 178600-17-4
Molecular Formula: C₁₈H₂₂ClNO₄
Molecular Weight: 351.82500
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-06-11 10:11:22
Modify Date: 2024-01-08 19:40:17
Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect[1].

Name	2-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethoxy]phenyl]acetic acid,hydrochloride
Synonyms	Talibegron hydrochloride Talibegron HCl CDP 840 hydrochloride ZD 2079 ICID2079

Description	Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vitro	Talibegron hydrochloride (ZD2079 hydrochloride; 0.01-1000 μM) produces a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries and causes full relaxation with 1 mM[1].
References	[1]. Hanna Kozłowska, et al. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol. 2003 Sep;140(1):3-12.