Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: P-1075
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

60559-98-0

60559-98-0 structure
60559-98-0 structure
  • Name: P1075
  • Chemical Name: 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-ylguanidine
  • CAS Number: 60559-98-0
  • Molecular Formula: C12H17N5
  • Molecular Weight: 231.30
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
  • Create Date: 2017-03-13 01:56:02
  • Modify Date: 2024-01-18 11:01:53
  • P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

Name 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-ylguanidine
Synonyms p-1075
Description P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
Related Catalog
Target

EC50: 45 nM (SUR2-KIR6)[1].

References

[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35.

[2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42.

Density 1.07g/cm3
Boiling Point 347.6ºC at 760 mmHg
Melting Point 186-187 °C
Molecular Formula C12H17N5
Molecular Weight 231.30
Flash Point 164.1ºC
Exact Mass 231.14800
PSA 73.10000
LogP 2.57268
Index of Refraction 1.556

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF0175400
CHEMICAL NAME :
Guanidine, 2-cyano-1-tert-pentyl-3-(3-pyridyl)-
CAS REGISTRY NUMBER :
60559-98-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H17-N5
MOLECULAR WEIGHT :
231.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,773,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,773,1978
Hazard Codes T+
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%