313981-55-4

313981-55-4 structure

Name: o-3M3FBS
Chemical Name: 2,4,6-trimethyl-N-[2-(trifluoromethyl)phenyl]benzenesulfonamide
CAS Number: 313981-55-4
Molecular Formula: C₁₆H₁₆F₃NO₂S
Molecular Weight: 343.36400
Catalog: Research Areas Others
Create Date: 2018-12-05 18:56:26
Modify Date: 2024-06-29 20:06:13
o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner[1].

Name	2,4,6-trimethyl-N-[2-(trifluoromethyl)phenyl]benzenesulfonamide
Synonyms	HMS3268M14 O-3M3FBS Tocris-1942

Description	o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	o-3M3FBS (10 μM) decreases AUC from 1058±189 g/min in control (in the presence of TTX) to 840±134 g/min. Higher concentration of o-3M3FBS (25 μM) further decreases AUC to 457±59 g/min[1].
References	[1]. Dwyer L, et al. Phospholipase C-independent effects of 3M3FBS in murine colon. Eur J Pharmacol. 2010;628(1-3):187-194.