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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Pyridine,2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-, hydrochloride(1:1)
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550-70-9

550-70-9 structure

Name: Triprolidine hydrochloride
Chemical Name: triprolidine hydrochloride (anh.)
CAS Number: 550-70-9
Molecular Formula: C₁₉H₂₃ClN₂
Molecular Weight: 314.85200
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-12-25 18:20:36
Modify Date: 2024-01-09 20:14:35
Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].

Name	triprolidine hydrochloride (anh.)
Synonyms	EINECS 208-985-0 MFCD00039044 Triprolidine Hydrochloride Triprolidine HCl

Description	Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
In Vivo	Triprolidine (292.81-1467.20 μg/kg; intrathecal injection) produces a dose-dependent effect of spinal motor and sensory block in rats[3]. Animal Model: Male Sprague-Dawley rat (300-350 g)[3] Dosage: 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg Administration: Intrathecal injection Result: Elicited a dose-dependent spinal block.
References	[1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30. [2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7. [3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.

Density	1.061g/cm3
Boiling Point	435.4ºC at 760mmHg
Melting Point	59-61ºC
Molecular Formula	C₁₉H₂₃ClN₂
Molecular Weight	314.85200
Flash Point	217.1ºC
Exact Mass	314.15500
PSA	16.13000
LogP	4.65740
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT7657000

CHEMICAL NAME :: Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, (E)-

CAS REGISTRY NUMBER :: 550-70-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H22-N2.Cl-H

MOLECULAR WEIGHT :: 314.89

WISWESSER LINE NOTATION :: T6NJ BYR D1&2- AT5NTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 495 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 247 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >5 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81570 No. of Facilities: 842 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81570 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2378 (estimated) No. of Female Employees: 1467 (estimated)

Hazard Codes	Xn
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	UT7658000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

486-12-4

~51%

550-70-9

Literature: HIKAL LIMITED Patent: WO2009/84035 A1, 2009 ; Location in patent: Page/Page column 11-12 ;

13573-69-8

550-70-9

Literature: WO2007/141803 A2, ; Page/Page column 6-7 ;

Precursor 1
486-12-4
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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