Name | 5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
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Synonyms |
5-(Methylthio)-1-(3-pyridylcarbamoyl)-6-(trifluoromethyl)indoline
Tocris-1379 |
Description | SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1]. |
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Related Catalog | |
Target |
5-HT2A Receptor:6.4 (pKi) 5-HT2B Receptor:7.9 (pKi) 5-HT2C Receptor:8.6 (pKi) |
In Vivo | SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1]. SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1] Animal Model: Male Sprague Dawley rats (250–360 g)[1] Dosage: 0.1~1 mg/kg Administration: I.p. Result: Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801. Animal Model: Male Sprague Dawley rats (250–360 g)[1] Dosage: 1 mg/kg Administration: I.p. Result: Significantly enhanced the magnitude and duration of the increase induced by phencyclidine. |
References |
Density | 1.43g/cm3 |
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Boiling Point | 536.2ºC at 760 mmHg |
Molecular Formula | C16H14F3N3OS |
Molecular Weight | 353.36200 |
Flash Point | 278.1ºC |
Exact Mass | 353.08100 |
PSA | 70.53000 |
LogP | 4.55490 |
Vapour Pressure | 1.43E-11mmHg at 25°C |
Index of Refraction | 1.621 |