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  • DC Chemicals Limited
  • China
  • Product Name: AF12198
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

185413-30-3

185413-30-3 structure
185413-30-3 structure
  • Name: AF12198
  • Chemical Name: af 12198
  • CAS Number: 185413-30-3
  • Molecular Formula: C96H123N19O22
  • Molecular Weight: 1895.12000
  • Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
  • Create Date: 2018-12-27 06:11:23
  • Modify Date: 2024-04-03 09:16:05
  • AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].

Name af 12198
Synonyms Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2
Description AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].
Related Catalog
Target

IC50: 8 nM (human IL1R1)[1]

References

[1]. F Aimbire, et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation

[2]. A L Akeson, et al.AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem. 1996 Nov 29;271(48):30517-23.

Density 1.354 g/cm3
Molecular Formula C96H123N19O22
Molecular Weight 1895.12000
Exact Mass 1893.91000
PSA 625.88000
LogP 5.63910