Name | cAMPS-Rp, triethylammonium salt,(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium |
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Synonyms |
sp-camps triethyl ammonium salt
rp-adenosine 3',5'-cyclic monophosphothioate triethylamine MFCD03703495 sp-adenosine 3',5'-cyclic monophosphothioate triethylamine sp-camps triethylamine sp-camps tea camps-sp,triethylammonium salt camps tea,sp-isomer rp-camps triethylamine |
Description | Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. |
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Related Catalog | |
Target |
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1] |
In Vitro | A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2]. |
In Vivo | Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2]. |
References |
Molecular Formula | C16H27N6O5PS |
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Molecular Weight | 446.46200 |
Exact Mass | 446.15000 |
PSA | 186.46000 |
LogP | 2.04940 |
Safety Phrases | S22-S24/25 |
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