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85532-75-8

85532-75-8 structure
85532-75-8 structure
  • Name: PK11195
  • Chemical Name: 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
  • CAS Number: 85532-75-8
  • Molecular Formula: C21H21ClN2O
  • Molecular Weight: 352.857
  • Catalog: Signaling Pathways Anti-infection Parasite
  • Create Date: 2018-12-24 16:00:34
  • Modify Date: 2024-01-03 10:00:33
  • PK-11195 is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
Name 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Synonyms N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide
UNII:YNF83VN1RL
MFCD00069334
3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-
N-sec-Butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
Description PK-11195 is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
Related Catalog
Target

IC50: 14.2 μM (L. amazonensis), 8.2 μM (L. major), 3.5 μM (L. braziliensis)[1].

In Vitro Median IC50 values for PK-11195 are 14.2 μM for L. amazonensis, 8.2 μM for L. major, and 3.5 μM for L. braziliensis. The selective index value for L. amazonensis is 13.7, indicating the safety of PK-11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK-11195[1].
References

[1]. Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.
Density 1.2±0.1 g/cm3
Boiling Point 511.7±45.0 °C at 760 mmHg
Melting Point 74-75
Molecular Formula C21H21ClN2O
Molecular Weight 352.857
Flash Point 263.3±28.7 °C
Exact Mass 352.134247
PSA 33.20000
LogP 4.58
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.611
Storage condition Store at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW6987000
CHEMICAL NAME :
3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-
CAS REGISTRY NUMBER :
85532-75-8
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H21-Cl-N2-O
MOLECULAR WEIGHT :
352.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - mouse Fibroblast
DOSE/DURATION :
1 nmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NW6987000

Chemsrc provides CAS#:85532-75-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 85532-75-8 | Chemsrc address: https://www.chemsrc.com/en/baike/671974.html

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