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143-19-1

143-19-1 structure
143-19-1 structure

Name sodium oleate
Synonyms Sodium oleate
sodium cis-9-octadecanoate
eunatrol
Lunac SO 90L
olateflakes
EINECS 205-591-0
Pionin D 951P
Approx
Oleic acid,sodium salt
Nonsoul ON 1
Nonsoul ON-A
cis-9-Octadecenoic acid sodium salt,Oleic acid sodium salt
sodiunm oleate
osteum
SodiumOleatePure
MFCD00004438
cis-Oleate sodium salt
Oleic Acid Sodium Salt
Description Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].
Related Catalog
Target

Na+/K+ ATPase[2]

In Vitro Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines[1].
References

[1]. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330.

[2]. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8.

Density 0.9 g/cm3
Boiling Point 359.999ºC at 760 mmHg
Melting Point 232-235 °C(lit.)
Molecular Formula C18H33NaO2
Molecular Weight 304.443
Flash Point 270.099ºC
Exact Mass 304.237823
PSA 40.13000
LogP 4.77380
Storage condition −20°C
Stability Stable. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK1200000
CHEMICAL NAME :
Oleic acid, sodium salt
CAS REGISTRY NUMBER :
143-19-1
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C18-H33-O2.Na
MOLECULAR WEIGHT :
304.50
WISWESSER LINE NOTATION :
QV8U9 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,327,1970
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,221,1925 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0760 No. of Facilities: 11635 (estimated) No. of Industries: 91 No. of Occupations: 92 No. of Employees: 122970 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0760 No. of Facilities: 8020 (estimated) No. of Industries: 88 No. of Occupations: 92 No. of Employees: 162242 (estimated) No. of Female Employees: 33454 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS RK1200000
HS Code 2916150000

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143-19-1 structure

143-19-1

Literature: WO2007/6334 A1, ; Page/Page column 8 ;

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Detail
Literature: Journal of the American Chemical Society, , vol. 74, p. 4419,4420
HS Code 2916150000
Summary 2916150000 oleic, linoleic or linolenic acids, their salts and esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%