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52089-62-0

52089-62-0 structure
52089-62-0 structure
  • Name: Diethyl (2H4)butanedioate
  • Chemical Name: diethyl 2,2,3,3-tetradeuteriobutanedioate
  • CAS Number: 52089-62-0
  • Molecular Formula: C8H10D4O4
  • Molecular Weight: 178.219
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-11-22 18:44:49
  • Modify Date: 2024-01-08 17:07:23
  • Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
Name diethyl 2,2,3,3-tetradeuteriobutanedioate
Synonyms Diethyl (H)butanedioate
Diethyl succinate-2,2,3,3-d4
Diethyl butanedioate-2,2,3,3-d4
Butanedioic-d acid, diethyl ester
MFCD00075229
Description Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134(2):934-43.  

Density 1.0±0.1 g/cm3
Boiling Point 218.4±8.0 °C at 760 mmHg
Melting Point -20ºC(lit.)
Molecular Formula C8H10D4O4
Molecular Weight 178.219
Flash Point 90.6±0.0 °C
Exact Mass 178.114319
PSA 52.60000
LogP 1.26
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.423
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
Precursor  1

DownStream  0


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title: CAS No. 52089-62-0 | Chemsrc address: https://www.chemsrc.com/en/baike/684748.html

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