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China
Product Name: Ribostamycin sulfate
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China
Product Name: Ribostamycin sulfate
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DC Chemicals Limited
China
Product Name: Ribostamycin sulfate
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Ribostamycin sulfate
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ribostamycin sulfate
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53797-35-6

53797-35-6 structure

Name: Ribostamycin sulfate
Chemical Name: ribostamycin sulfate
CAS Number: 53797-35-6
Molecular Formula: C₁₇H₃₆N₄O₁₄S
Molecular Weight: 552.551
Catalog: API Antibiotics Aminoglycoside
Create Date: 2018-03-22 08:00:00
Modify Date: 2024-01-02 23:56:26
Ribostamycin is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

Name	ribostamycin sulfate
Synonyms	α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(β-D-ribofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxy-, sulfate (1:1) (salt) Riboflavine Sulfate Ribostamycin sulfate salt EINECS 258-783-1 MFCD00057496 Vistamycin (1R,2R,3S,4R,6S)-4,6-Diamino-3-hydroxy-2-(β-D-ribofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside sulfate (1:1) Ribostamycin sulfate Ribostamycin (sulfate)

Description	Ribostamycin is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	1.6g/cm3
Boiling Point	907.6ºC at 760 mmHg
Melting Point	175-180ºC
Molecular Formula	C₁₇H₃₆N₄O₁₄S
Molecular Weight	552.551
Flash Point	502.7ºC
Exact Mass	552.194885
PSA	345.36000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2300000

CHEMICAL NAME :: Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4 )-O-(beta-D- ribofuranosyl-(1-5))-2-deoxy-, sulfate

CAS REGISTRY NUMBER :: 53797-35-6

LAST UPDATED :: 199603

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C17-H34-N4-O10.xH2-O4-S

MOLECULAR WEIGHT :: 1141.11

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ F1Z BO- BL6TJ AZ DQ EZ CO- BT5OTJ CQ DQ E1Q &WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,885,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3080 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMGZAI Japan Medical Gazette. (Tokyo, Japan) V.1-18(?), 1964-81. Discontinued. Volume(issue)/page/year: 10(2),5,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMGZAI Japan Medical Gazette. (Tokyo, Japan) V.1-18(?), 1964-81. Discontinued. Volume(issue)/page/year: 10(2),5,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2030 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,885,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,885,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1981 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMGZAI Japan Medical Gazette. (Tokyo, Japan) V.1-18(?), 1964-81. Discontinued. Volume(issue)/page/year: 10(2),5,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1561 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H312-H332-H360
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T,Xi
Risk Phrases	R61
Safety Phrases	S22-S45-S53-S36-S37-S39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WK2300000

53797-35-6	38363-32-5
60585-57-1	1228182-35-1
10333-92-3	87587-61-9
20997-99-3	63653-42-9
65-30-5	7446-18-6
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	1904645-88-0
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1