132541-52-7
132541-52-7 structure
- Name: HNMPA
- Chemical Name: [Hydroxy(2-naphthyl)methyl]phosphonic acid
- CAS Number: 132541-52-7
- Molecular Formula: C11H11O4P
- Molecular Weight: 238.17600
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Insulin Receptor
- Create Date: 2016-03-13 00:48:26
- Modify Date: 2024-01-02 18:24:33
-
HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
| Name | [Hydroxy(2-naphthyl)methyl]phosphonic acid |
|---|---|
| Synonyms | 2-naphthylhydroxymethylphosphonate |
| Description | HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2] |
|---|---|
| Related Catalog | |
| In Vitro | HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2]. |
| References |
| Density | 1.514g/cm3 |
|---|---|
| Boiling Point | 527.2ºC at 760mmHg |
| Molecular Formula | C11H11O4P |
| Molecular Weight | 238.17600 |
| Flash Point | 272.6ºC |
| Exact Mass | 238.03900 |
| PSA | 87.57000 |
| LogP | 2.00840 |
| Hazard Codes | Xi |
|---|
|
~82%
132541-52-7 |
| Literature: Burke Jr.; Li; Bolen; Marquez Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1577 - 1581 |
|
~%
132541-52-7 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 9 p. 1295 - 1298 |
|
~%
132541-52-7 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 17 p. 2169 - 2172 |
