Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: HNMPA
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

132541-52-7

132541-52-7 structure
132541-52-7 structure
  • Name: HNMPA
  • Chemical Name: [Hydroxy(2-naphthyl)methyl]phosphonic acid
  • CAS Number: 132541-52-7
  • Molecular Formula: C11H11O4P
  • Molecular Weight: 238.17600
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Insulin Receptor
  • Create Date: 2016-03-13 00:48:26
  • Modify Date: 2024-01-02 18:24:33
  • HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

Name [Hydroxy(2-naphthyl)methyl]phosphonic acid
Synonyms 2-naphthylhydroxymethylphosphonate
Description HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
Related Catalog
In Vitro HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].
References

[1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9.

[2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93.

Density 1.514g/cm3
Boiling Point 527.2ºC at 760mmHg
Molecular Formula C11H11O4P
Molecular Weight 238.17600
Flash Point 272.6ºC
Exact Mass 238.03900
PSA 87.57000
LogP 2.00840
Hazard Codes Xi

~82%

132541-52-7 structure

132541-52-7

Literature: Burke Jr.; Li; Bolen; Marquez Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1577 - 1581

~%

132541-52-7 structure

132541-52-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 9 p. 1295 - 1298

~%

132541-52-7 structure

132541-52-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 17 p. 2169 - 2172
Precursor  2

DownStream  0