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111374-21-1

111374-21-1 structure
111374-21-1 structure
  • Name: HSR6071
  • Chemical Name: 6-(1-Pyrrolidinyl)-N-(2H-tetrazol-5-yl)-2-pyrazinecarboxamide
  • CAS Number: 111374-21-1
  • Molecular Formula: C10H12N8O
  • Molecular Weight: 260.25500
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2017-02-24 18:30:20
  • Modify Date: 2024-01-09 18:54:04
  • HSR6071 is an antiallergic agent with potential for the treatment of asthma.
Name 6-(1-Pyrrolidinyl)-N-(2H-tetrazol-5-yl)-2-pyrazinecarboxamide
Synonyms 6-(1-Pyrazolyl)-2-quinolone
2(1H)-Quinolinone,6-(1H-pyrazol-1-yl)
6-(1-pyrrolidinyl)-N-(1H-tetrazol-5-yl)-2-pyrazine-5-carboxamide
HSR6071
Description HSR6071 is an antiallergic agent with potential for the treatment of asthma.
Related Catalog
In Vivo HSR-6071 suppresses antigen-induced histamine and SRS-A release from minced lung tissues of guinea-pigs sensitized passively with rabbit anti-EA serum and is a more potent inhibitor of the release of SRS-A than of histamine. On the other hand, histamine- or acetylcholine-induced bronchoconstriction in guinea-pigs is scarcely affected by HSR-6071 at doses sufficient to inhibit the experimental asthma, but LTD4-induced bronchoconstriction is dramatically inhibited. HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea[1]. HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract[2].
Animal Admin Rats: In order to find out the proper pre treatment time with HSR-6071, 0.03 mg/kg, i.vi or 1 mg/kg, p.o. of HSR-6071 was given at varying times before the antigen challenge[2].
References

[1]. Makino E, et al. Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. J Pharm Pharmacol. 1990 Apr;42(4):236-41.

[2]. Makino E, et al. Potent inhibitory activity of HSR-6071, a new antiallergic agent, on passive cutaneousanaphylaxis (PCA). Jpn J Pharmacol. 1990 Jan;52(1):87-94.
Density 1.555g/cm3
Molecular Formula C10H12N8O
Molecular Weight 260.25500
Exact Mass 260.11300
PSA 116.07000
LogP 0.29120
Index of Refraction 1.717
Storage condition 2-8℃

Chemsrc provides CAS#:111374-21-1 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 111374-21-1 | Chemsrc address: https://www.chemsrc.com/en/baike/689700.html

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