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69579-13-1

69579-13-1 structure
69579-13-1 structure
  • Name: GYKI-11679
  • Chemical Name: tert-butyl (3E)-3-[(6-morpholin-4-ylpyridazin-3-yl)hydrazinylidene]butanoate
  • CAS Number: 69579-13-1
  • Molecular Formula: C16H25N5O3
  • Molecular Weight: 335.40100
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2017-04-20 07:41:08
  • Modify Date: 2024-01-02 14:45:10
  • GYKI-11679 is a new antihypertensive agent.
Name tert-butyl (3E)-3-[(6-morpholin-4-ylpyridazin-3-yl)hydrazinylidene]butanoate
Synonyms GYKI-11679
Description GYKI-11679 is a new antihypertensive agent.
Related Catalog
In Vivo GYKI-11679 is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of GYKI-11679, and this effect lasts for 4 to 6 h. It is demonstrated that GYKI-11679 exerts a greater NA lowering effect in the hypothalamus than in the periphery. GYKI-11679 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment[1].
Animal Admin Rats are used and treated with GYKI-11679 (0.5 mL of 1% Tween 80 suspension) at various dosages. They are killed at the specified times by decapitation; the heart is immediately removed, cut open, and rinsed in an isotonic saline solution. The brain is placed on ice and the hypothalamus is dissected. The tissues are weighed, homogenized in 5% trichloroacetic acid (TCA) containing 0.2% EDTA and ascorbic acid, and centrifuged for 1 h at 5000×g. The supernatant is processed on alumina and noradrenaline in the eluate is determined spectrofluorimetrically[1].
References

[1]. Huszti Z, et al. Influence on turnover and level of hypothalamic noradrenaline by a new antihypertensive agent (GYKI 11679). J Neurochem. 1981 Nov;37(5):1272-81.
Density 1.22g/cm3
Boiling Point 528.421ºC at 760 mmHg
Molecular Formula C16H25N5O3
Molecular Weight 335.40100
Flash Point 273.38ºC
Exact Mass 335.19600
PSA 92.17000
LogP 1.31970
Index of Refraction 1.574
17259-72-2 structure

17259-72-2

1694-31-1 structure

1694-31-1

~53%

69579-13-1 structure

69579-13-1

Literature: Szilagyi; Kasztreiner; Matyus; et al. European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 111 - 117

Chemsrc provides CAS#:69579-13-1 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 69579-13-1 | Chemsrc address: https://www.chemsrc.com/en/baike/692033.html

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