66663-91-0

66663-91-0 structure

Name: Polygalacin D
Chemical Name: polygalacin D
CAS Number: 66663-91-0
Molecular Formula: C₅₇H₉₂O₂₇
Molecular Weight: 1209.324
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-09-18 20:24:46
Modify Date: 2024-01-01 18:36:45
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]

Name	polygalacin D
Synonyms	α-L-Arabinopyranose, O-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-xylopyranosyl-(1->4)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β,16α)-3-(β- D-glucopyranosyloxy)-2,16,23-trihydroxy-28-oxoolean-12-en-28-yl]- polygalacin-D POLYGALACIN D 3-O-[(2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β,16α)-3-(β-D-glucopyranosyloxy)-2,16,23-t ; rihydroxy-28-oxoolean-12-en-28-yl]-α-L-arabinopyranose

Description	Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> IAP
Target	IC50: IAP[1]
In Vitro	Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1]. Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1]. Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM, 40µM Incubation Time: 48 hours Result: Inhibited the proliferation of NSCLC cell lines. Apoptosis Analysis[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Induced apoptosis of NSCLC cell lines. Western Blot Analysis[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression.
References	[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710.

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₇H₉₂O₂₇
Molecular Weight	1209.324
Exact Mass	1208.582642
PSA	433.05000
LogP	0.50
Index of Refraction	1.652
Storage condition	2-8℃

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