1054629-49-0
1054629-49-0 structure
- Name: AZD4694
- Chemical Name: 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol
- CAS Number: 1054629-49-0
- Molecular Formula: C14H11FN2O2
- Molecular Weight: 258.24800
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2019-01-10 20:00:21
- Modify Date: 2024-01-07 10:42:51
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AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].
| Name | 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol |
|---|---|
| Synonyms |
unii-g5k506j69e
azd 4694 |
| Description | AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 2.3 nM (Aβ) |
| In Vivo | Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1]. AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1]. Animal Model: Male Sprague–Dawley rats (275-300 g)[1] Dosage: 4 mL/kg Administration: I.v. Result: Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. |
| References |
| Molecular Formula | C14H11FN2O2 |
|---|---|
| Molecular Weight | 258.24800 |
| Exact Mass | 258.08000 |
| PSA | 61.52000 |
| LogP | 2.80310 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |