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  • DC Chemicals Limited
  • China
  • Product Name: SMND-309
  • Price: $1050.0/100mg $2100.0/250mg $4200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
Related CAS#:
1065559-56-9 100402-80-0
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1065559-56-9

1065559-56-9 structure
1065559-56-9 structure
  • Name: SMND-309
  • Chemical Name: (E)-2-[6-[(E)-2-carboxyethenyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
  • CAS Number: 1065559-56-9
  • Molecular Formula: C18H14O8
  • Molecular Weight: 358.29900
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2016-09-11 14:11:56
  • Modify Date: 2024-01-07 09:20:37
  • SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo. IC50 value:Target: SMND-309 mitigated the effects of ischemia and reperfusion injury on brain by decreasing the infract volume, improving neurological function, increasing the survival of neurons and promoting angiogenesis by increasing the levels of erythropoietin (EPO), erythropoietin receptor (EPOR), phosphorylated JAK2 (P-JAK2), phosphorylated STAT3 (P-STAT3), VEGF and VEGF receptor 2 (Flk-1) in the brain.
Name (E)-2-[6-[(E)-2-carboxyethenyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Synonyms SMND-309||SMND309
CS-0559
SMND309
salvianolic acid E
SMND-309
Description SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo. IC50 value:Target: SMND-309 mitigated the effects of ischemia and reperfusion injury on brain by decreasing the infract volume, improving neurological function, increasing the survival of neurons and promoting angiogenesis by increasing the levels of erythropoietin (EPO), erythropoietin receptor (EPOR), phosphorylated JAK2 (P-JAK2), phosphorylated STAT3 (P-STAT3), VEGF and VEGF receptor 2 (Flk-1) in the brain.
Related Catalog
References

[1]. Hou J, Tian J, Jiang W, Gao Y, Fu F. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Eur J Pharmacol. 2011 Jan 10;650(1):390-5.

[2]. Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23.

[3]. Tian J, Fu F, Li G, Wang Y, Gao Y, Liu Z, Zhang S. SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role. Brain Res. 2009 Mar 31;1263:114-21.

[4]. Tian J, Li G, Zhang S, Gao Y, Jiang W, Fu F, Liu Z. SMND-309, a novel derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons. Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):176-84.

[5]. Jian Hou et al. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis European Journal of Pharmacology Volume 650, Issue 1, 10 January 2011, Pages 390-395
Molecular Formula C18H14O8
Molecular Weight 358.29900
Exact Mass 358.06900
PSA 155.52000
LogP 2.23200
Storage condition 2-8℃

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title: CAS No. 1065559-56-9 | Chemsrc address: https://www.chemsrc.com/en/baike/694318.html

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