Name | 2-[[4-[2-[dimethyl(oxido)azaniumyl]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]-N,N-dimethylethanamine oxide |
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Synonyms |
Banoxantrone
1,4-Bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide 1,4-Bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-9,10-anthracenedione N,N'-dioxide 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione AQ4N 1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroanthracene-9,10-dione 1,4-bis-(2-dimethylamino-ethylamino)-5,8-dihydroxy-anthraquinone-bis-N-oxide Banoxantrone [INN:BAN] UNII-W5H7E45YT3 1,4-Bis(2-(dimethylazinoyl)ethylamino)-5,8-dihydroxy-9,10-anthraquinone |
Description | Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation[1][2]. |
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Related Catalog | |
Target |
iNOS |
In Vitro | Banoxantrone (20 μM; 90 min) 选择性诱导缺氧的 T50/80 肿瘤细胞发生损伤[1]。 |
In Vivo | Banoxantrone (200 mg/kg; 腹腔注射; 单剂量) 在 BDF 小鼠中显著抑制T50/80肿瘤,并诱导细胞损伤[1]。 |
References |
Molecular Formula | C22H28N4O6 |
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Molecular Weight | 444.48100 |
Exact Mass | 444.20100 |
PSA | 157.52000 |
LogP | 2.03320 |
~% 136470-65-0 |
Literature: KUDOS PHARMACEUTICALS LIMITED Patent: WO2005/80314 A2, 2005 ; Location in patent: Page/Page column title page; 17; 20 ; WO 2005/080314 A2 |
~% 136470-65-0 |
Literature: Lee, Ho H.; Denny, William A. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2755 - 2758 |
~% 136470-65-0 |
Literature: Lee, Ho H.; Denny, William A. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2755 - 2758 |
~% 136470-65-0 |
Literature: Lee, Ho H.; Denny, William A. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2755 - 2758 |
~% 136470-65-0 |
Literature: Lee, Ho H.; Denny, William A. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2755 - 2758 |
~% 136470-65-0 |
Literature: Lee, Ho H.; Denny, William A. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2755 - 2758 |
Precursor 6 | |
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DownStream 0 |