791620-96-7

791620-96-7 structure

Name: Thiol-PEG8-alcohol
Chemical Name: 2-[2-[2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
CAS Number: 791620-96-7
Molecular Formula: C₁₆H₃₄O₈S
Molecular Weight: 386.50100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-10-02 09:36:18
Modify Date: 2024-01-10 12:05:48
Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonyms	3,6,9,12,15,18,21-Heptaoxatricosan-1-ol,23-mercapto Thiol-PEG8-alcohol

Description	Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.