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  • DC Chemicals Limited
  • China
  • Product Name: EF24
  • Price: $550.0/100mg $850.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

342808-40-6

342808-40-6 structure
342808-40-6 structure
  • Name: EF24
  • Chemical Name: (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride
  • CAS Number: 342808-40-6
  • Molecular Formula: C19H16ClF2NO
  • Molecular Weight: 347.78600
  • Catalog: Signaling Pathways Apoptosis Caspase
  • Create Date: 2016-10-09 06:37:51
  • Modify Date: 2024-01-05 19:10:19
  • EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].

Name (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride
Synonyms EF-24
(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone
Description EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].
Related Catalog
References

[1]. Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834.

[2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.

Molecular Formula C19H16ClF2NO
Molecular Weight 347.78600
Exact Mass 347.08900
PSA 29.10000
LogP 4.73490
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P273
RIDADR UN 3077 9 / PGIII