342808-40-6
342808-40-6 structure
- Name: EF24
- Chemical Name: (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride
- CAS Number: 342808-40-6
- Molecular Formula: C19H16ClF2NO
- Molecular Weight: 347.78600
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2016-10-09 06:37:51
- Modify Date: 2024-01-05 19:10:19
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EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].
| Name | (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride |
|---|---|
| Synonyms |
EF-24
(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone |
| Description | EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2]. |
|---|---|
| Related Catalog | |
| References |
[2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103. |
| Molecular Formula | C19H16ClF2NO |
|---|---|
| Molecular Weight | 347.78600 |
| Exact Mass | 347.08900 |
| PSA | 29.10000 |
| LogP | 4.73490 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| RIDADR | UN 3077 9 / PGIII |
| Precursor 4 | |
|---|---|
| DownStream 0 | |