81045-50-3
81045-50-3 structure
- Name: Pivopril
- Chemical Name: (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine
- CAS Number: 81045-50-3
- Molecular Formula: C16H27NO4S
- Molecular Weight: 329.45500
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
- Create Date: 2016-09-06 13:49:13
- Modify Date: 2024-01-13 18:45:45
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Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.
| Name | (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine |
|---|---|
| Synonyms |
Pivalopril
Pivopril |
| Description | Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor. |
|---|---|
| Related Catalog | |
| Target |
ACE[1] |
| In Vivo | Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2]. |
| References |
| Density | 1.16g/cm3 |
|---|---|
| Boiling Point | 490.431°C at 760 mmHg |
| Molecular Formula | C16H27NO4S |
| Molecular Weight | 329.45500 |
| Flash Point | 250.4±26.8 °C |
| Exact Mass | 329.16600 |
| PSA | 99.98000 |
| LogP | 2.78420 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2-8℃ |