Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dynorphin A 1-10?
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

GL Biochem (Shanghai) Ltd.
China
Product Name: YGGFLRRIRP
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Taiwan Oyi peptide Co. Ltd
China
Product Name: Dynorphin A (1-10) acetate salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

79994-24-4

79994-24-4 structure

79994-24-4 structure

Name: Dynorphin A (1-10) acetate salt
Chemical Name: Dynorphin A (1-10), porcine,YGGFLRRIRP
CAS Number: 79994-24-4
Molecular Formula: C₅₇H₉₁N₁₉O₁₂
Molecular Weight: 1234.45000
Catalog: Peptides
Create Date: 2018-12-20 19:22:37
Modify Date: 2024-01-10 21:00:14
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

Name	Dynorphin A (1-10), porcine,YGGFLRRIRP
Synonyms	YGGFLRRIRP dynorphin A fragment 1-10 porcine*sequence DYNORPHIN A (1-10),PORCINE DYNORPHIN A (1-10) dynorphin A,porcine,fragment 1-10 OPIOID AGONIST H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO

Description	Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Peptides Research Areas >> Neurological Disease
Target	κ-opioid receptor[1] NMDA receptor[2]
In Vitro	Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2].
References	[1]. Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. [2]. Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31.

Molecular Formula	C₅₇H₉₁N₁₉O₁₂
Molecular Weight	1234.45000
Exact Mass	1233.71000
PSA	522.36000
LogP	3.94170
Storage condition	2-8℃