103476-21-7

103476-21-7 structure

Name: DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium
Chemical Name: (DL-3-Hydroxy-3-methylglutaryl)-coenzyme A disodium salt trihydrate
CAS Number: 103476-21-7
Molecular Formula: C₂₇H₄₂N₇Na₂O₂₀P₃S
Molecular Weight: 955.623
Catalog: Research Areas Metabolic Disease
Create Date: 2018-12-14 15:02:16
Modify Date: 2024-01-06 19:57:28
DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].

Name	(DL-3-Hydroxy-3-methylglutaryl)-coenzyme A disodium salt trihydrate
Synonyms	DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate Adenosine, 5'-O-[[[[(3R)-4-[[3-[[2-[(4-carboxy-3-hydroxy-3-methyl-1-oxobutyl)thio]ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), sodium salt (1:2) Disodium (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[(9R)-22-carboxy-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-3,5-dioxido-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3λ,5λ-diphosphad ocos-1-yl]-4-hydroxytetrahydro-3-furanyl phosphate

Description	DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	3-hydroxy-3-methylglutaryl CoA (HMG-CoA) comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria[1].
References	[1]. Millán Núñez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish. [2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.

WGK Germany	3.0