DC Chemicals Limited
China
Product Name: Doramectin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g $150.0/10ml
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Doramectin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

117704-25-3

117704-25-3 structure

Name: Doramectin
Chemical Name: doramectin
CAS Number: 117704-25-3
Molecular Formula: C₅₀H₇₄O₁₄
Molecular Weight: 899.114
Catalog: API Antiparasitic drug Anthelmintic
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-02 22:00:25
Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.

Name	doramectin
Synonyms	Doromectin extended von Baeyer nomenclature: (10E,14E,16E)-(1R,4S,5’S,6S,6’R,8R,12S,13S,20R,21R,24S)-6’-cyclohexyl-21,24-dihydroxy-5’,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2’-(5’,6’-dihydro-2’H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Doramectina Doramectin 25-cyclohexyl-avermectin B1 DONGGUAI.P.E bridged fused ring systems nomenclature: (2aE,4E,8E)-(5’S,6S,6’R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-6’-cyclohexyl-5’,6,6’,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5’,6,8,19-tetramethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2’-[2H]pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Dectoma Dectomax 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a Doramecin

Description	Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol. [2]. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295. [3]. Sarre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T. Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium. Vet Parasitol. 2012 Apr 30;185(2-4):346-51. [4]. Lobetti R. .Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. [5]. Wang JB, Pan HX, Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3320-3.

Density	1.3±0.1 g/cm3
Boiling Point	967.4±65.0 °C at 760 mmHg
Melting Point	116 - 119ºC
Molecular Formula	C₅₀H₇₄O₁₄
Molecular Weight	899.114
Flash Point	274.4±27.8 °C
Exact Mass	898.507874
PSA	170.06000
LogP	7.16
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.580
Storage condition	0-6°C
Water Solubility	methanol: soluble

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T,N,Xi
Risk Phrases	R25
Safety Phrases	33-45-60-61-36/37-26
RIDADR	UN 2811 6.1/PG 3

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