174635-53-1

174635-53-1 structure

Name: SB 218795
Chemical Name: methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate
CAS Number: 174635-53-1
Molecular Formula: C₂₅H₂₀N₂O₃
Molecular Weight: 396.44
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2017-04-25 01:55:33
Modify Date: 2024-01-11 16:00:35
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].

Name	methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate

Description	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	hNK3:13 nM (Ki) hNK2:1220 nM (Ki)
In Vitro	SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner[2]. SB 218795 (0.3-3 μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle[2].
In Vivo	SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2].
References	[1]. Giardina GA, et, al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J Med Chem. 1997 Jun 6;40(12):1794-807. [2]. Medhurst AD, et, al. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br J Pharmacol. 1997 Oct;122(3):469-76. [3]. Valero MS, et, al. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin. 2011 Apr;32(4):487-94.

Density	1.237g/cm3
Boiling Point	623.7ºC at 760 mmHg
Molecular Formula	C₂₅H₂₀N₂O₃
Molecular Weight	396.44
Flash Point	331ºC
Exact Mass	396.14700
PSA	68.29000
LogP	4.93680
Vapour Pressure	1.78E-15mmHg at 25°C
Index of Refraction	1.643
Storage condition	-20°C

98-86-2

174635-53-1

Literature: Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065

132-60-5

174635-53-1

132-60-5

19883-41-1

174635-53-1

Literature: Giardina; Sarau; Farina; Medhurst; Grugni; Foley; Raveglia; Schmidt; Rigolio; Vassallo; Vecchietti; Hay Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2281 - 2284

132-60-5

24461-61-8

174635-53-1

Literature: Giardina, Giuseppe A. M.; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Grugni, Mario; Raveglia, Luca F.; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Vecchietti, Vittorio; Hay, Douglas W. P. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1794 - 1807

59661-86-8

19883-41-1

174635-53-1

Precursor 5
98-86-2 132-60-5 19883-41-1 24461-61-8
59661-86-8
DownStream 0

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