423169-68-0

423169-68-0 structure

Name: SC-57461A
Chemical Name: 3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid,hydrochloride
CAS Number: 423169-68-0
Molecular Formula: C₂₀H₂₆ClNO₃
Molecular Weight: 363.87800
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aminopeptidase
Create Date: 2017-03-09 17:05:38
Modify Date: 2024-04-05 20:19:16
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively[1].

Name	3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid,hydrochloride
Synonyms	MFCD00951253

Description	SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase Research Areas >> Inflammation/Immunology
In Vitro	SC-57461A inhibits ionophore-stimulated LTB4 production in whole blood with IC50s of 49, 166, and 466 nM in human mouse and rat, respectively[1].SC-57461A demonstrates excellent potency against LTA4 hydrolase (IC50=2.5 nM) and in whole cells (IC50=49 nM)[2]<
In Vivo	SC-57461A also shows excellent potency in the mouse ex vivo assay, inhibiting the production of LTB4 with an ED50=0.2 mg/kg and an ED90=1 mg/kg. SC-57461A also inhibits the production of LTB4 in the rat peritoneal model with an ED50=1 mg/kg[2]. SC-57461A is a potent, selective, and competitive inhibitor of LTA4 hydrolase with excellent activity in whole animals. SC-57461A demonstrates good oral activity in both the mouse and the rat[3]. Animal Model: Fasted CD rats[3] Dosage: 0.01, 0.1, 1, and 10 mg/kg Administration: Orally administered Result: The ED50 values were 0.2 mg/kg at 1.0 h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg blocked LTB4 production 79% at 6 h, 67% at 18 h, and 44% at 24 h.
References	[1]. Leslie J Askonas, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82. [2]. T D Penning. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des. 2001 Feb;7(3):163-79. [3]. James F Kachur, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.

Density	1.115g/cm3
Boiling Point	499.7ºC at 760 mmHg
Molecular Formula	C₂₀H₂₆ClNO₃
Molecular Weight	363.87800
Flash Point	256.01ºC
Exact Mass	363.16000
PSA	49.77000
LogP	4.25480
Index of Refraction	1.562
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	22-36/37/38
RIDADR	NONH for all modes of transport

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