681260-70-8

681260-70-8 structure

Name: Astressin 2B
Chemical Name: Astressin2B trifluoroacetate salt
CAS Number: 681260-70-8
Molecular Formula: C₁₈₃H₃₀₇N₄₉O₅₃
Molecular Weight: 4041.69000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2017-10-27 19:37:22
Modify Date: 2024-01-27 21:11:47
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].

Name	Astressin2B trifluoroacetate salt
Synonyms	Astressin 2B

Description	Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Others
References	[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747. [2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470. [3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.

Safety Phrases	22-24/25