- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: MIRA-1
- Price:
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Huang
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: NSC 19630
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: NSC 19630
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (2,5-dioxopyrrol-1-yl)methyl propanoate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
72835-26-8
72835-26-8 structure
- Name: MIRA-1
- Chemical Name: (2,5-dioxopyrrol-1-yl)methyl propanoate
- CAS Number: 72835-26-8
- Molecular Formula: C8H9NO4
- Molecular Weight: 183.16
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-12-26 20:18:22
- Modify Date: 2024-01-12 11:29:44
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MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].
| Name | (2,5-dioxopyrrol-1-yl)methyl propanoate |
|---|---|
| Synonyms |
MIRA-1
N-propionyloxymethyl-maleimide N-Propionyloxymethyl-maleinimid NSC 19630 |
| Description | MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 10 μM (Saos-2 His273)[1] |
| In Vitro | MIRA-1 suppresses growth of Saos-2-His273 cells expressing mutant p53[1]. MIRA-1 (25 μM; 48 hours) inhibits cell growth in a mutant p53-dependent manner[1]. MIRA-1 (5 μM; 14 days) dramatically reduces the number of colonies formed by His273-expressing Saos-2 cells, but is much less efficient in inhibiting p53-null Saos-2 cells[1]. MIRA-1 (10 μM; 48 hours) causes a substantial increase in the fraction of Saos-2 and Saos-2-His273 cells with a sub-G1 DNA content in the presence of mutant p53[1]. MIRA-1 (5 and 10 μM; 24 hours) induces EGFP expression, MDM2 and Bax in SKOV-His175 cells[1]. Cell Proliferation Assay Cell Line: Saos-2-His273, H1299-His175, SKOV-His175 and SKOV-His273[1] Concentration: 25 μM Incubation Time: 48 hours Result: Inhibited cell growth in a mutant p53-dependent manner, with survival rate of 18.5~39% in no doxycycline and 71.5~87.5% in doxycycline. Apoptosis Analysis Cell Line: Saos-2 and Saos-2-His273 cells[1] Concentration: 10 μM Incubation Time: 48 hours Result: Caused a substantial increase in the fraction of cells with a sub-G1 DNA content in the presence of mutant p53. |
| References |
| Density | 1.307g/cm3 |
|---|---|
| Boiling Point | 298.2ºC at 760 mmHg |
| Molecular Formula | C8H9NO4 |
| Molecular Weight | 183.16 |
| Flash Point | 134.1ºC |
| Exact Mass | 183.05300 |
| PSA | 63.68000 |
| Index of Refraction | 1.514 |
| Storage condition | 2-8°C |
