97548-97-5

97548-97-5 structure

Name: Quinelorane hydrochloride
Chemical Name: (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine,dihydrochloride
CAS Number: 97548-97-5
Molecular Formula: C₁₄H₂₄Cl₂N₄
Molecular Weight: 319.27300
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-12 17:50:13
Modify Date: 2024-01-09 12:11:17
Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research[1][2].

Name	(5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine,dihydrochloride
Synonyms	Quinelorane HCl Quinelorane dihydrochloride LY-163,502 Quinerlorane hydrochloride

Description	Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor D3 Receptor
In Vivo	Quinelorane dihydrochloride (LY163502; 0.003, 0.01 mg/kg; s.c.) reduces GABA efflux, with significant effects with 0.01 but not 0.003 mg/kg in male Wistar rats (300 g)[1]. Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1]. Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].
References	[1]. Ying Qu, et al. Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies. Pharmacol Biochem Behav. 2008 Oct;90(4):686-90. [2]. Morgane Thomsen, et al. Psychomotor stimulation by dopamine D₁-like but not D₂-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011 Oct;19(5):342-60.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport