86-04-4

86-04-4 structure
86-04-4 structure
  • Name: inosine 5'-(trihydrogen diphosphate)
  • Chemical Name: idp
  • CAS Number: 86-04-4
  • Molecular Formula: C10H13N4O15P3--
  • Molecular Weight: 522.14900
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2017-12-05 18:12:47
  • Modify Date: 2024-01-03 18:37:21
  • Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation[1][2].

Name idp
Synonyms O5'-trihydroxydiphosphoryl-inosine
riboxine
Inosindiphosphat
Inosine 5'-pyrophosphate
Inosin-5'-diphosphat
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate
Inosine diphosphate
Inosine 5'-diphosphate
5'-inosine diphosphate
Riboxin
Description Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation[1][2].
Related Catalog
In Vivo Riboxin (250 mg/kg; 口服; 单剂量) 可增加小鼠的游泳时间,但对力量耐力无显著影响。在相同条件下,Riboxin 提高了热室实验中动物的存活率[1]。 Riboxin (50 mg/kg; 口服; 每天1次,持续6天) 增加小鼠游走的时间,而对游泳和跑步的时间无显著影响[1]。 Riboxin (250 mg/kg; 口服; 实验前 1 小时) 对小鼠有明显的 γ 辐照保护作用[1]。
References

[1]. Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.

[2]. Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.

Density 2.49g/cm3
Boiling Point 925.2ºC at 760 mmHg
Molecular Formula C10H13N4O15P3--
Molecular Weight 522.14900
Flash Point 513.3ºC
Exact Mass 521.95900
PSA 328.66000
Index of Refraction 1.883

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM7515000
CHEMICAL NAME :
Inosine 5'-(trihydrogen pyrophosphate)
CAS REGISTRY NUMBER :
86-04-4
LAST UPDATED :
199707
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H14-N4-O11-P2
MOLECULAR WEIGHT :
428.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 51,100,1988