Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Imiclopazine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Imiclopazine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Imidazolidone dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

7414-95-1

7414-95-1 structure

7414-95-1 structure

Name: Imiclopazine
Chemical Name: Imidazolidone dihydrochloride
CAS Number: 7414-95-1
Molecular Formula: C₂₅H₃₂ClN₅OS
Molecular Weight: 486.07200
Catalog: Research Areas Neurological Disease
Create Date: 2016-03-19 02:28:42
Modify Date: 2024-01-05 19:28:41
Imiclopazine is a phenothiazine derivative with good sedative, analgesic, antiaggressive and antiemetic effects[1].

Name	Imidazolidone dihydrochloride
Synonyms	Chlorimpiphenine dihydrochloride Chorimpiphenine P-4241 Chlorimiphene dichloride Ponsital Imiclopazine hydrochloride Chlorimphenine hydrochloride Imiclopazine dihydrochloride Asta p 4241

Description	Imiclopazine is a phenothiazine derivative with good sedative, analgesic, antiaggressive and antiemetic effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Imiclopazine shows multidrug-resistance (MDR)-reversal activity in P388 and P388/ADR cells, with EC50 values of both 200 μM[2].
References	[1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73. [2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

Density	1.252g/cm3
Boiling Point	659.8ºC at 760mmHg
Molecular Formula	C₂₅H₃₂ClN₅OS
Molecular Weight	486.07200
Flash Point	352.8ºC
Exact Mass	485.20200
PSA	58.57000
LogP	4.13440

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ0621400

CHEMICAL NAME :: 2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-pipe razinyl)ethyl)-3- methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 7414-95-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H32-Cl-N5-O-S.2Cl-H

MOLECULAR WEIGHT :: 559.05

WISWESSER LINE NOTATION :: T C666 BN ISJ EG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 321 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967