466-09-1

466-09-1 structure

Name: Odorigenin
Chemical Name: 3β,14-dihydroxy-5α,14β-card-20(22)-enolide
CAS Number: 466-09-1
Molecular Formula: C₂₃H₃₄O₄
Molecular Weight: 374.514
Catalog: Natural product Steroidal compound
Create Date: 2018-07-17 12:40:51
Modify Date: 2024-01-10 08:05:36
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].

Name	3β,14-dihydroxy-5α,14β-card-20(22)-enolide
Synonyms	Odorigenin 5α-Card-20(22)-enolide, 3β,14-dihydroxy- 3b,14-Dihydroxy-5a-card-20(22)-enolide UZARIGENIN ODORIGENIN B Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5α)- (3β,5α)-3,14-Dihydroxycard-20(22)-enolide uzarigenine

Description	Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1029,1970 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963

Hazard Codes	Xi