Odorigenin

Modify Date: 2024-01-10 08:05:36

Odorigenin Structure
Odorigenin structure
Common Name Odorigenin
CAS Number 466-09-1 Molecular Weight 374.514
Density 1.2±0.1 g/cm3 Boiling Point 549.3±50.0 °C at 760 mmHg
Molecular Formula C23H34O4 Melting Point 240-256°
MSDS N/A Flash Point 188.2±23.6 °C

 Use of Odorigenin


Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].

 Names

Name 3β,14-dihydroxy-5α,14β-card-20(22)-enolide
Synonym More Synonyms

 Odorigenin Biological Activity

Description Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].
Related Catalog
References

[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 549.3±50.0 °C at 760 mmHg
Melting Point 240-256°
Molecular Formula C23H34O4
Molecular Weight 374.514
Flash Point 188.2±23.6 °C
Exact Mass 374.245697
PSA 66.76000
LogP 2.79
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.591

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV1950000
CHEMICAL NAME :
Uzarigenin
CAS REGISTRY NUMBER :
466-09-1
BEILSTEIN REFERENCE NO. :
0095446
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H34-O4
MOLECULAR WEIGHT :
374.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1379 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1029,1970 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963

 Safety Information

Hazard Codes Xi

 Synonyms

Odorigenin
5α-Card-20(22)-enolide, 3β,14-dihydroxy-
3b,14-Dihydroxy-5a-card-20(22)-enolide
UZARIGENIN
ODORIGENIN B
Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5α)-
(3β,5α)-3,14-Dihydroxycard-20(22)-enolide
uzarigenine
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