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145224-92-6

145224-92-6 structure
145224-92-6 structure
  • Name: Sodium deoxycholate monohydrate
  • Chemical Name: Sodium Deoxycholate Monohydrate
  • CAS Number: 145224-92-6
  • Molecular Formula: C24H41NaO5
  • Molecular Weight: 432.56900
  • Catalog: Signaling Pathways GPCR/G Protein GPCR19
  • Create Date: 2018-07-21 17:30:11
  • Modify Date: 2024-01-04 17:03:58
  • Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].
Name Sodium Deoxycholate Monohydrate
Synonyms MFCD00150750
EINECS 206-132-7
Sodium deoxycholate monohydrate
sodium,(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate
DEOXYCHOLIC ACID SODIUM SALT MONOHYDRATE
Description Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].
Related Catalog
Target

Microbial Metabolite

In Vitro Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress[2]. Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells[2].
References

[1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.

[2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.
Boiling Point 581.5ºC at 760mmHg
Melting Point >300ºC
Molecular Formula C24H41NaO5
Molecular Weight 432.56900
Flash Point 319.5ºC
Exact Mass 432.28500
PSA 89.82000
LogP 3.07890
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H335
Precautionary Statements P261
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R22;R37
Safety Phrases S22-S26-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3.0

Chemsrc provides CAS#:145224-92-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 145224-92-6 | Chemsrc address: https://www.chemsrc.com/en/baike/763628.html

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