1207961-33-8
1207961-33-8 structure
- Name: PF-4942847
- Chemical Name: 2-amino-4-[4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxamide
- CAS Number: 1207961-33-8
- Molecular Formula: C22H23ClF3N7O2
- Molecular Weight: 509.91200
- Create Date: 2018-12-15 19:35:27
- Modify Date: 2024-01-31 15:40:41
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An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.
| Name | 2-amino-4-[4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxamide |
|---|---|
| Synonyms |
2-Amino-4-(4-chloro-2-(2-(4-fluoro-1H-pyrazol-1-yl)ethoxy)-6-methylphenyl)-N-(2,2-difluoropropyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide
2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoropropyl)amide |
| Molecular Formula | C22H23ClF3N7O2 |
|---|---|
| Molecular Weight | 509.91200 |
| Exact Mass | 509.15500 |
| PSA | 111.19000 |
| LogP | 4.69260 |
| Precursor 10 | |
|---|---|
| DownStream 0 | |
![4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine structure](https://image.chemsrc.com/caspic/035/1207961-60-1.png)
![2-(4-Chloro-2-Methoxy-6-Methyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane structure](https://image.chemsrc.com/caspic/107/1207961-49-6.png)
![2-amino-4-iodo-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/290/1046861-23-7.png)
![2-amino-4-(4-chloro-2-hydroxy-6-methylphenyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/145/1207961-48-5.png)
![2-amino-4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester structure](https://image.chemsrc.com/caspic/497/1207961-61-2.png)
