150145-89-4

150145-89-4 structure

Name: (S)-MCPG
Chemical Name: (s)-alpha-methyl-4-carboxyphenylglycine
CAS Number: 150145-89-4
Molecular Formula: C₁₀H₁₁NO₄
Molecular Weight: 209.19900
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2018-12-21 18:15:49
Modify Date: 2024-01-02 09:36:25
(S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG.

Name	(s)-alpha-methyl-4-carboxyphenylglycine
Synonyms	(+)-MCPG (S)-alpha-Methyl-4-carboxyphenylglycine 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid (S)-MCPG

Description	(S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Bordi F et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65. [2]. Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol. 1996 Apr;117(7):1493-503. [3]. Jane DE et al. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 1993 Jul;32(7):725-7.

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HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%