1215751-27-1

1215751-27-1 structure

Name: Physcion-d3
Chemical Name: 1,8-dihydroxy-3-methyl-6-(trideuteriomethoxy)anthracene-9,10-dione
CAS Number: 1215751-27-1
Molecular Formula: C₁₆H₉D₃O₅
Molecular Weight: 287.28200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-07-22 21:05:36
Modify Date: 2024-01-05 10:02:54
Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[1][2][3].

Name	1,8-dihydroxy-3-methyl-6-(trideuteriomethoxy)anthracene-9,10-dione
Synonyms	6-(Methoxy-d3)chrysophanic Acid Parietin-d3 6-O-Methylemodin-d3 1,8-Dihydroxy-3-methyl-6-(methoxy-d3)anthraquinone Emodin 3-(Methyl-d3) Ether Rheochrysidin-d3 Physcion-d3

Description	Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [3]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.