182133-25-1

182133-25-1 structure

Name: Arzoxifene
Chemical Name: 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
CAS Number: 182133-25-1
Molecular Formula: C₂₈H₂₉NO₄S
Molecular Weight: 475.59900
Catalog: Research Areas Metabolic Disease
Create Date: 2018-07-24 09:49:53
Modify Date: 2024-01-05 19:16:35
Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].

Name	2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
Synonyms	Arzoxifene UNII-E569WG6E60

Description	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Metabolic Disease
Target	estrogen[1]
In Vitro	Arzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)[1].
In Vivo	Arzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats[1].
References	[1]. Jackson LR, et al. Arzoxifene: the evidence for its development in the management of breast cancer. Core Evid. 2008;2(4):251-258.